![]() Very few tumors and cancers have a single known cause. The reason why a particular pet may develop this, or any tumor or cancer, is not straightforward. Limbal melanomas develop from the melanocytes found at the limbus, the border of the cornea (transparent front part of the eye) and the sclera (white part of the eye). ![]() Limbal (sometimes called epibulbar) melanomas are less common. ![]() The rate of metastasis (spread to other areas of the body) is less than 5%. About 80% of uveal melanomas are benign (non-cancerous). Most uveal tumors arise from the iris or ciliary body (part of the wall of the eye that makes the fluid that fills the eye). These melanomas grow from the tissues that make up the uvea (the iris, ciliary body, and choroid). Uveal melanomas are the most common primary intraocular tumor in dogs. There are two kinds of ocular melanomas in dogs, uveal melanomas and limbal melanomas. Melanin is a pigment that gives skin, hair, and eyes their color. In the eye, they can be found in the iris (the thin, circular structure in the eye that gives the eye its color and controls the size of the pupil), as well as beneath the retina (the thin layer of tissue that lines the back of the eye). Melanocytes are cells found throughout the body in many tissues (e.g., skin, eye, inner ear, bones, and heart). A melanoma of the eye is a type of cancer that develops from the disorganized uncontrolled proliferation of melanocytes.
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